OUR MISSION
The Lawler Lab investigates therapeutic approaches for treating brain cancer, from preclinical models to analyzing data from patient tumors, with the goal of developing the next generation of therapeutic approaches for these extremely challenging diseases.
Research Teams
Targeting the innate, antiviral cGAS–STING pathway has emerged as a promising approach to boost immune cell infiltration and vascular remodeling in cancer. We are currently investigating the role of STING pathway activation in GBM-associated endothelium.
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This project focuses on looking for combination therapies using 6-bromoindirubin acetoxime (BIA), a derivative of indirubin, which exhibits anti-inflammatory, anti-tumor, and neuroprotective properties. We are currently investigating the effects of pairing BIA with Poly(ADP-ribose) glycohydrolase inhibitors (PARGi) and/or temozolomide (TMZ).
The Lawler Lab 